Cargando…

Complex Mitochondrial Dysfunction Induced by TPP(+)-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, 10-((2,5-dihydroxybenzoyl)oxy)decyl) triphenylphosphonium bromide (GA-TPP(+)C(10)),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuentes-Retamal, Sebastián, Sandoval-Acuña, Cristian, Peredo-Silva, Liliana, Guzmán-Rivera, Daniela, Pavani, Mario, Torrealba, Natalia, Truksa, Jaroslav, Castro-Castillo, Vicente, Catalán, Mabel, Kemmerling, Ulrike, Urra, Félix A., Ferreira, Jorge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072465/ https://www.ncbi.nlm.nih.gov/pubmed/32053908 http://dx.doi.org/10.3390/cells9020407

Ejemplares similares

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)
por: Ozsvari, Bela, et al.
Publicado: (2018)

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy
por: Fiesel, Fabienne C., et al.
Publicado: (2017)

Theophylline–gentisic acid (1/1)
por: Aitipamula, Srinivasulu, et al.
Publicado: (2009)

Shedding Light on the Dentition and Venom Delivery System of the Rear-Fanged Snake, Galvarinus chilensis chilensis (Serpentes: Dipsadidae: Tachymenini) from Chile
por: Herrera, Yarela, et al.
Publicado: (2022)

INHIBITION OF THE SECONDARY ANTIBODY RESPONSE IN VITRO BY SALICYLATE AND GENTISATE
por: Ambrose, Charles Tesch
Publicado: (1966)

Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis
por: Urra, Félix A., et al.
Publicado: (2021)

Mitochondrial-targeting Mn(3)O(4)/UIO-TPP nanozyme scavenge ROS to restore mitochondrial function for osteoarthritis therapy
por: Zhang, Shengqing, et al.
Publicado: (2023)

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function
por: Wüst, Rob C. I., et al.
Publicado: (2021)

The Apoptosis of Liver Cancer Cells Promoted by Curcumin/TPP-CZL Nanomicelles With Mitochondrial Targeting Function
por: Li, Wanyu, et al.
Publicado: (2022)

The TPP scheduler
por: Marrocchesi, P S, et al.
Publicado: (1987)

Ethenzamide–gentisic acid–acetic acid (2/1/1)
por: Aitipamula, Srinivasulu, et al.
Publicado: (2010)

Novel absorbance peak of gentisic acid following the oxidation reaction
por: Hosokawa, Sho, et al.
Publicado: (2020)

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
por: Shlevkov, Evgeny, et al.
Publicado: (2019)

Intravenous Transplantation of an Ischemic-specific Peptide-TPP-mitochondrial Compound Alleviates Myocardial Ischemic Reperfusion Injury
por: Sun, Xiaolei, et al.
Publicado: (2023)

The TPP Is Dead, Long Live the TPP? A Response to Recent Commentaries
por: Labonté, Ronald, et al.
Publicado: (2017)

Biochemical and Molecular Characterization of the Gentisate Transporter GenK in Corynebacterium glutamicum
por: Xu, Ying, et al.
Publicado: (2012)

Antioxidant activity and mechanism of inhibitory action of gentisic and α-resorcylic acids
por: Mardani-Ghahfarokhi, Azadeh, et al.
Publicado: (2020)

Insight into Gentisic Acid Antidiabetic Potential Using In Vitro and In Silico Approaches
por: Mechchate, Hamza, et al.
Publicado: (2021)

Engineering a Synthetic Pathway for Gentisate in Pseudomonas Chlororaphis P3
por: Wang, Songwei, et al.
Publicado: (2021)

ALEPH - TPP TPPLIB
por: Marrocchesi, P S
Publicado: (1989)

TPP software outline
por: Amendolia, S R, et al.
Publicado: (1987)

Beyond the TPP(+) “gold standard”: a new generation mitochondrial delivery vector based on extended PN frameworks
por: Ong, How Chee, et al.
Publicado: (2023)

Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid
por: Tárraga, Susana, et al.
Publicado: (2010)

Gentisic Acid Stimulates Keratinocyte Proliferation through ERK1/2 Phosphorylation
por: Kim, Minho, et al.
Publicado: (2020)

Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
por: Angevine, Devin J., et al.
Publicado: (2022)

FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells
por: Córdova-Delgado, Miguel, et al.
Publicado: (2021)

The TPP Fastbus Library FBLIB
por: Lusiani, A
Publicado: (1993)

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation
por: Wang, Bo, et al.
Publicado: (2021)

Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs
por: Mink, Steven, et al.
Publicado: (2016)

Homogentisic Acid and Gentisic Acid Biosynthesized Pyomelanin Mimics: Structural Characterization and Antioxidant Activity
por: Al Khatib, Maher, et al.
Publicado: (2021)

The protective effect of gentisic acid on rheumatoid arthritis via the RAF/ERK signaling pathway
por: Dong, Xiaojun, et al.
Publicado: (2022)

Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure
por: Riba, Adam, et al.
Publicado: (2017)

TFNLIB: TPP Fastbus Network Library
por: Lusiani, A
Publicado: (1993)

ALEPH TPP FastBus Library
por: Marrocchesi, P S
Publicado: (1990)

Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts
por: Van Beersel, Guillaume, et al.
Publicado: (2013)

Gentisic acid prevents the transition from pressure overload-induced cardiac hypertrophy to heart failure
por: Sun, Simei, et al.
Publicado: (2019)

Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster
por: Salminen, Tiina S., et al.
Publicado: (2019)

Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity
por: Catalán, Mabel, et al.
Publicado: (2020)

Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy
por: Tan, Qian, et al.
Publicado: (2017)

The Mitochondrial Complex(I)ty of Cancer
por: Urra, Félix A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qt027brd4h6s3ajf0a2sldf9ti