Cargando…

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events. Accordingly, assays evaluating micronucleus formation serve as useful tools within...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lepage, Chloe C., Thompson, Laura L., Larson, Bradley, McManus, Kirk J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072510/ https://www.ncbi.nlm.nih.gov/pubmed/32024251 http://dx.doi.org/10.3390/cells9020344

Ejemplares similares

HIV Infection, Chromosome Instability, and Micronucleus Formation
por: Ellwanger, Joel Henrique, et al.
Publicado: (2023)

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
por: Thompson, Laura L., et al.
Publicado: (2017)

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity
por: Lepage, Chloe C., et al.
Publicado: (2019)

Determination of Genotoxic Effects of Hookah Smoking by Micronucleus and Chromosome Aberration Methods
por: Eker, Ebru Derici, et al.
Publicado: (2016)

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2021)

Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2022)

Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes
por: Vishwakarma, Raghvendra, et al.
Publicado: (2020)

A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells
por: Thompson, Laura L., et al.
Publicado: (2015)

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
por: Cisyk, Amy L., et al.
Publicado: (2018)

Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests
por: Chiu, Yi-Jen, et al.
Publicado: (2013)

Using the micronucleus assay to detect genotoxic effects of metal ions.
por: Bérces, J, et al.
Publicado: (1993)

The micronucleus test—most widely used in vivo genotoxicity test—
por: Hayashi, Makoto
Publicado: (2016)

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests
por: Melzi, Gloria, et al.
Publicado: (2022)

Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice
por: Afzal, Muhammad, et al.
Publicado: (2020)

Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer
por: Lepage, Chloe Camille, et al.
Publicado: (2021)

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
por: Sajesh, Babu V, et al.
Publicado: (2013)

Genotoxicity Evaluation of Capsaicin-Containing (CP) Pharmacopuncture, in an In Vivo Micronucleus Test
por: Hwang, Ji Hye, et al.
Publicado: (2020)

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover
por: Thompson, Laura L., et al.
Publicado: (2020)

The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations.
por: Fenech, M
Publicado: (1993)

Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability
por: Fenech, Michael
Publicado: (2020)

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
por: Baergen, Allison K., et al.
Publicado: (2019)

Genotoxicity evaluation of Guibi-Tang extract using an in vitro bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus test
por: Lee, Mee-Young, et al.
Publicado: (2014)

Micronucleus cytome assay in the differential assessment of cytotoxicity and genotoxicity of cadmium and lead in Amietophrynus regularis
por: Alimba, C.G., et al.
Publicado: (2018)

Anti-Genotoxicity Evaluation of Cratoxylum Formosum Dyer Leaves by Comet Assay and Micronucleus Test
por: Praphasawat, Ratsada, et al.
Publicado: (2017)

Genotoxicity in Oral Mucosal Epithelial Cells of Petrol Station Attendants: A Micronucleus Study
por: Rehani, Shweta, et al.
Publicado: (2021)

Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes
por: Leylek, Tarik R., et al.
Publicado: (2020)

Combining the in vivo comet and micronucleus assays: a practical approach to genotoxicity testing and data interpretation
por: Vasquez, Marie Z.
Publicado: (2010)

Evaluation of Genotoxicity in Patients Subjected to Panoramic Radiography by Micronucleus Assay on Epithelial Cells of the Oral Mucosa
por: Arora, Pallak, et al.
Publicado: (2014)

Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review
por: Torres-Bugarín, Olivia, et al.
Publicado: (2015)

Genotoxic evaluation of the River Paranaíba hydrographic basin in Monte Carmelo, MG, Brazil, by the Tradescantia micronucleus
por: Campos, Carlos F., et al.
Publicado: (2015)

Genotoxicity of Heterocyclic PAHs in the Micronucleus Assay with the Fish Liver Cell Line RTL-W1
por: Brinkmann, Markus, et al.
Publicado: (2014)

Evaluation of genotoxicity by micronucleus assay in oral leukoplakia and oral squamous cell carcinoma with deleterious habits
por: Singam, Praveen Kumar, et al.
Publicado: (2019)

A micronucleus assay detects genotoxic effects of herbicide exposure in a protected butterfly species
por: Santovito, Alfredo, et al.
Publicado: (2020)

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells
por: Cervena, Tereza, et al.
Publicado: (2021)

A Comparative Evaluation of the Genotoxic Effects of Mobile Phone Radiation Using Buccal Micronucleus Assay
por: Kadeh, Hamideh, et al.
Publicado: (2023)

Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells
por: Buick, Julie K., et al.
Publicado: (2020)

The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition
por: McAndrew, Erin N., et al.
Publicado: (2016)

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples
por: Penner-Goeke, Signe, et al.
Publicado: (2017)

Assessment of Genotoxicity Among Rubber Industry Workers Occupationally Exposed to Toxic Agents Using Micronucleus Assay
por: Gemitha, Gem, et al.
Publicado: (2013)

Investigation of the Genotoxic Potential of the Marine Toxin C17-SAMT Using the In Vivo Comet and Micronucleus Assays
por: Marzougui, Zeineb, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_38krbbatg8jlon8kpcih4b9pcm