Biphasic Mathematical Model of Cell–Drug Interaction That Separates Target-Specific and Off-Target Inhibition and Suggests Potent Targeted Drug Combinations for Multi-Driver Colorectal Cancer Cells

Quantifying the response of cancer cells to a drug, and understanding the mechanistic basis of the response, are the cornerstones for anti-cancer drug discovery. Classical single target-based IC(50) measurements are inadequate at describing cancer cell responses to targeted drugs. In this study, bas...

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Detalles Bibliográficos
Autores principales: Shen, Jinyan, Li, Li, Yang, Tao, Cohen, Paul S., Sun, Gongqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072552/
https://www.ncbi.nlm.nih.gov/pubmed/32069833
http://dx.doi.org/10.3390/cancers12020436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072552/
https://www.ncbi.nlm.nih.gov/pubmed/32069833
http://dx.doi.org/10.3390/cancers12020436

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