Relevance of Hydrogen Bonds for the Histamine H2 Receptor-Ligand Interactions: A Lesson from Deuteration†

We used a combination of density functional theory (DFT) calculations and the implicit quantization of the acidic N–H and O–H bonds to assess the effect of deuteration on the binding of agonists (2-methylhistamine and 4-methylhistamine) and antagonists (cimetidine and famotidine) to the histamine H2...

Descripción completa

Detalles Bibliográficos
Autores principales: Kržan, Mojca, Keuschler, Jan, Mavri, Janez, Vianello, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072573/
https://www.ncbi.nlm.nih.gov/pubmed/32013143
http://dx.doi.org/10.3390/biom10020196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072573/
https://www.ncbi.nlm.nih.gov/pubmed/32013143
http://dx.doi.org/10.3390/biom10020196

Ejemplares similares