Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-G(D2) CAR Expression and Inducible Cytokines

Genetically modified T cells expressing chimeric antigen receptors (CARs) so far have mostly failed in the treatment of solid tumors owing to a number of limitations, including an immunosuppressive tumor microenvironment and insufficient CAR T cell activation and persistence. Next-generation approac...

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Detalles Bibliográficos
Autores principales: Zimmermann, Katharina, Kuehle, Johannes, Dragon, Anna Christina, Galla, Melanie, Kloth, Christina, Rudek, Loreen Sophie, Sandalcioglu, I. Erol, Neyazi, Belal, Moritz, Thomas, Meyer, Johann, Rossig, Claudia, Altvater, Bianca, Eiz-Vesper, Britta, Morgan, Michael Alexander, Abken, Hinrich, Schambach, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072617/
https://www.ncbi.nlm.nih.gov/pubmed/32041222
http://dx.doi.org/10.3390/cancers12020375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072617/
https://www.ncbi.nlm.nih.gov/pubmed/32041222
http://dx.doi.org/10.3390/cancers12020375

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