The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives

Insulin receptor overexpression is a common event in human cancer. Its overexpression is associated with a relative increase in the expression of its isoform A (IR(A)), a shorter variant lacking 11 aa in the extracellular domain, conferring high affinity for the binding of IGF-II along with added in...

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Detalles Bibliográficos
Autores principales: Scalia, Pierluigi, Giordano, Antonio, Williams, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072655/
https://www.ncbi.nlm.nih.gov/pubmed/32033443
http://dx.doi.org/10.3390/cancers12020366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072655/
https://www.ncbi.nlm.nih.gov/pubmed/32033443
http://dx.doi.org/10.3390/cancers12020366

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