Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma

Mitogen-activated protein kinase (MAPK) inhibition with the combination of BRAF (Rapidly Accelerated Fibrosarcoma) and MEK (Mitogen-activated protein kinase kinase) inhibitors has become the standard of first-line therapy of metastatic melanoma harbouring BRAF V600 mutations. However, about half of...

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Detalles Bibliográficos
Autores principales: Krayem, Mohamad, Aftimos, Philippe, Najem, Ahmad, van den Hooven, Tim, van den Berg, Adriënne, Hovestad-Bijl, Liesbeth, de Wijn, Rik, Hilhorst, Riet, Ruijtenbeek, Rob, Sabbah, Malak, Kerger, Joseph, Awada, Ahmad, Journe, Fabrice, Ghanem, Ghanem E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072684/
https://www.ncbi.nlm.nih.gov/pubmed/32098410
http://dx.doi.org/10.3390/cancers12020512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072684/
https://www.ncbi.nlm.nih.gov/pubmed/32098410
http://dx.doi.org/10.3390/cancers12020512

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