NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines

(1) Background: The structure of the Sigma 2 receptor/TMEM97 (σ2RTMEM97) has recently been reported. (2, 3) Methods and results: We used genetic and biochemical approaches to identify the molecular mechanism downstream of σ2R/TMEM97. The novel σ2R/TMEM97 fluorescent ligand, NO1, reduced the prolifer...

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Detalles Bibliográficos
Autores principales: Cantonero, Carlos, Camello, Pedro Javier, Abate, Carmen, Berardi, Francesco, Salido, Gines Maria, Rosado, Juan Antonio, Redondo, Pedro C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072710/
https://www.ncbi.nlm.nih.gov/pubmed/31973006
http://dx.doi.org/10.3390/cancers12020257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072710/
https://www.ncbi.nlm.nih.gov/pubmed/31973006
http://dx.doi.org/10.3390/cancers12020257

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