Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway

Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer cell vulnerability. While we reported that NPL...

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Detalles Bibliográficos
Autores principales: Majera, Dusana, Skrott, Zdenek, Chroma, Katarina, Merchut-Maya, Joanna Maria, Mistrik, Martin, Bartek, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072750/
https://www.ncbi.nlm.nih.gov/pubmed/32085572
http://dx.doi.org/10.3390/cells9020469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072750/
https://www.ncbi.nlm.nih.gov/pubmed/32085572
http://dx.doi.org/10.3390/cells9020469

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