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Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway
Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer cell vulnerability. While we reported that NPL...
Autores principales: | Majera, Dusana, Skrott, Zdenek, Chroma, Katarina, Merchut-Maya, Joanna Maria, Mistrik, Martin, Bartek, Jiri |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072750/ https://www.ncbi.nlm.nih.gov/pubmed/32085572 http://dx.doi.org/10.3390/cells9020469 |
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