Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes

The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To avoid the synthesis of these shortened polypeptides, several RNA surveillance sys...

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Detalles Bibliográficos
Autores principales: Lambert, Jean-Marie, Ashi, Mohamad Omar, Srour, Nivine, Delpy, Laurent, Saulière, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072976/
https://www.ncbi.nlm.nih.gov/pubmed/32079193
http://dx.doi.org/10.3390/ijms21041335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072976/
https://www.ncbi.nlm.nih.gov/pubmed/32079193
http://dx.doi.org/10.3390/ijms21041335

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