Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells

Dysfunction of the tumor suppressor p53 occurs in most human cancers. Mdm2 and MdmX are homologous proteins from the Mdm (Murine Double Minute) protein family, which play a critical role in p53 inactivation and degradation. The two proteins interact with one another via the intrinsic RING (Really In...

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Detalles Bibliográficos
Autores principales: Egorova, Olga, Lau, Heather HC, McGraphery, Kate, Sheng, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072982/
https://www.ncbi.nlm.nih.gov/pubmed/32075226
http://dx.doi.org/10.3390/ijms21041309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072982/
https://www.ncbi.nlm.nih.gov/pubmed/32075226
http://dx.doi.org/10.3390/ijms21041309

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