Cargando…

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

Ceramide kinase (CerK) is a lipid kinase that converts the proapoptotic ceramide to ceramide 1-phosphate, which has been proposed to have pro-malignant properties and regulate cell responses such as proliferation, migration, and inflammation. We used the parental human breast cancer cell line MDA-MB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schwalm, Stephanie, Erhardt, Martin, Römer, Isolde, Pfeilschifter, Josef, Zangemeister-Wittke, Uwe, Huwiler, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073039/ https://www.ncbi.nlm.nih.gov/pubmed/32092937 http://dx.doi.org/10.3390/ijms21041396

Ejemplares similares

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells
por: Blanchard, Olivier, et al.
Publicado: (2018)

Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis
por: Kotelevets, Nataliya, et al.
Publicado: (2012)

Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis
por: Kotelevets, Nataliya, et al.
Publicado: (2013)

Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways
por: Zhu, Shan, et al.
Publicado: (2021)

Implication of Ceramide Kinase in Adipogenesis
por: Ordoñez, Marta, et al.
Publicado: (2017)

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants
por: Hsieh, Louise Tzung-Harn, et al.
Publicado: (2017)

A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders
por: Huwiler, Andrea, et al.
Publicado: (2011)

Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine
por: Brunkhorst, R., et al.
Publicado: (2015)

Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
por: Wijesinghe, Dayanjan S., et al.
Publicado: (2014)

Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P
por: Ku, Chee Wai, et al.
Publicado: (2022)

Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
por: Grammatikos, Georgios, et al.
Publicado: (2016)

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge
por: Stepanovska, Bisera, et al.
Publicado: (2020)

Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation
por: León, Yolanda, et al.
Publicado: (2021)

Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels
por: Grammatikos, Georgios, et al.
Publicado: (2016)

A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide
por: Van Overloop, Helena, et al.
Publicado: (2012)

Spatiotemporal expression pattern of ceramide kinase-like in the mouse retina
por: Vekslin, Sharon, et al.
Publicado: (2010)

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity
por: Buchanan, Christina M., et al.
Publicado: (2013)

Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish
por: Chen, Shuang, et al.
Publicado: (2017)

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy
por: Ksionda, Olga, et al.
Publicado: (2018)

Hyperautofluorescent Dots are Characteristic in Ceramide Kinase Like-associated Retinal Degeneration
por: Sengillo, Jesse D., et al.
Publicado: (2019)

Control of Skeletal Muscle Atrophy Associated to Cancer or Corticosteroids by Ceramide Kinase
por: Pierucci, Federica, et al.
Publicado: (2021)

Implication of Ceramide Kinase/C1P in Cancer Development and Progression
por: Camacho, Laura, et al.
Publicado: (2022)

Characterization of an evolutionarily distinct bacterial ceramide kinase from Caulobacter crescentus
por: Dhakephalkar, Tanisha, et al.
Publicado: (2023)

The pair ceramide 1-phosphate/ceramide kinase regulates intracellular calcium and progesterone-induced human sperm acrosomal exocytosis
por: Vaquer, Cintia C., et al.
Publicado: (2023)

Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent
por: Greene, Meredith A., et al.
Publicado: (2015)

The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention
por: Peirce, Susan K., et al.
Publicado: (2010)

Polarization of Migrating Monocytic Cells Is Independent of PI 3-Kinase Activity
por: Volpe, Silvia, et al.
Publicado: (2010)

Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway
por: Ma, Zheng, et al.
Publicado: (2022)

Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke
por: Luger, Sebastian, et al.
Publicado: (2018)

A Conserved Cysteine Motif Is Critical for Rice Ceramide Kinase Activity and Function
por: Bi, Fang-Cheng, et al.
Publicado: (2011)

Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
por: Camacho, Laura, et al.
Publicado: (2021)

Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols
por: Beyoğlu, Diren, et al.
Publicado: (2023)

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts
por: Santio, Niina M., et al.
Publicado: (2015)

Ritonavir inhibits NF-AT activation through modulation of the PI-3 kinase/Akt Ppathway
por: Pati, Shibani, et al.
Publicado: (2006)

Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway
por: Quaresma, Alexandre Jose Christino, et al.
Publicado: (2013)

Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer
por: Tsang, Tiffany, et al.
Publicado: (2022)

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
por: Hafizi, Redona, et al.
Publicado: (2022)

Migration of Th1 Lymphocytes Is Regulated by CD152 (CTLA-4)-Mediated Signaling via PI3 Kinase-Dependent Akt Activation
por: Knieke, Karin, et al.
Publicado: (2012)

Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation
por: Yuan, Ling, et al.
Publicado: (2012)

Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling
por: Huwiler, Andrea, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jvd5k708c25hcabdg5j64p8hai