Cargando…

Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist

In vitro chondrogenically differentiated mesenchymal stem cells (MSCs) have a tendency to undergo hypertrophy, mirroring the fate of transient “chondrocytes” in the growth plate. As hypertrophy would result in ossification, this fact limits their use in cartilage tissue engineering applications. Dur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riedl, Moritz, Witzmann, Christina, Koch, Matthias, Lang, Siegmund, Kerschbaum, Maximilian, Baumann, Florian, Krutsch, Werner, Docheva, Denitsa, Alt, Volker, Pfeifer, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073129/ https://www.ncbi.nlm.nih.gov/pubmed/32093330 http://dx.doi.org/10.3390/ijms21041444

Ejemplares similares

Practical Relevance of Institutional Guidelines in Translational Large Animal Studies of Cartilage Repair—A Multidisciplinary Survey
por: Riedl, Moritz, et al.
Publicado: (2022)

Two-Dimensional Visualization of the Three-Dimensional Planned Sacroiliac Screw Corridor with the Slice Fusion Method
por: Kerschbaum, Maximilian, et al.
Publicado: (2021)

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts
por: Chu, Jin, et al.
Publicado: (2020)

Influence of Oral Anticoagulation and Antiplatelet Drugs on Outcome of Elderly Severely Injured Patients
por: Kerschbaum, Maximilian, et al.
Publicado: (2021)

The Loop Tenodesis Procedure—From Biomechanics to First Clinical Results
por: Riedl, Moritz, et al.
Publicado: (2021)

The All-Inside Arthroscopic Loop Tenodesis Procedure to Treat Long Head of Biceps Tendon Pathologies
por: Kerschbaum, Maximilian, et al.
Publicado: (2019)

Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model
por: Pattappa, Girish, et al.
Publicado: (2020)

Aged Tendon Stem/Progenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits
por: Yan, Zexing, et al.
Publicado: (2020)

Iliac Bone Corridors to Host the Transiliac Internal Fixator—An Experimental CT Based Analysis
por: Schmitz, Paul, et al.
Publicado: (2021)

Does Dynamic Anterior Plate Fixation Provide Adequate Stability for Traumatic Subaxial Cervical Spine Fractures at Mid-Term Follow-Up?
por: Lang, Siegmund, et al.
Publicado: (2021)

Football-related injuries are the major reason for the career end of professional male football players
por: Koch, Matthias, et al.
Publicado: (2021)

Are There Any Red Flag Injuries in Severely Injured Patients in Older Age?
por: Popp, Daniel, et al.
Publicado: (2021)

Radiological and mid- to long-term patient-reported outcome after stabilization of traumatic thoraco-lumbar spinal fractures using an expandable vertebral body replacement implant
por: Lang, Siegmund, et al.
Publicado: (2021)

Dexamethasone Is Not Sufficient to Facilitate Tenogenic Differentiation of Dermal Fibroblasts in a 3D Organoid Model
por: Kroner-Weigl, Niklas, et al.
Publicado: (2023)

The Tibial Plateau Map: Fracture Line Morphology of Intra-Articular Proximal Tibial Fractures
por: Kerschbaum, Maximilian, et al.
Publicado: (2021)

Reduced performance after return to competition in ACL injuries: an analysis on return to competition in the ‘ACL registry in German Football’
por: Szymski, Dominik, et al.
Publicado: (2022)

Higher Ratios of Hyaluronic Acid Enhance Chondrogenic Differentiation of Human MSCs in a Hyaluronic Acid–Gelatin Composite Scaffold
por: Pfeifer, Christian G., et al.
Publicado: (2016)

Antibiotic cement coating in orthopedic surgery: a systematic review of reported clinical techniques
por: Ismat, Abdullah, et al.
Publicado: (2021)

Changes of Material Elastic Properties during Healing of Ruptured Achilles Tendons Measured with Shear Wave Elastography: A Pilot Study
por: Frankewycz, Borys, et al.
Publicado: (2020)

Clinical Value of CT for Differentiation between Ascites and Hemorrhage: An Experimental In-Vitro Study
por: Kerschbaum, Maximilian, et al.
Publicado: (2020)

Injury Profile and Sex-Specific Differences in Bubble-Soccer – A First Scientific Survey of a Dangerous New Sports Trend
por: Krutsch, Volker, et al.
Publicado: (2020)

Epidemiological analysis of injury occurrence and current prevention strategies on international amateur football level during the UEFA Regions Cup 2019
por: Szymski, Dominik, et al.
Publicado: (2021)

Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
por: Stich, Theresia, et al.
Publicado: (2021)

Synthesis of A-9758, an Inverse Agonist of Retinoic Acid-Related Orphan Receptor γt
por: Marvin, Christopher C., et al.
Publicado: (2022)

Displacement of the Greater Tuberosity in Humeral Head Fractures Does Not only Depend on Rotator Cuff Status
por: Klute, Lisa, et al.
Publicado: (2021)

Understanding Tendons: Lessons from Transgenic Mouse Models
por: Delgado Caceres, Manuel, et al.
Publicado: (2018)

Standardized Rehabilitation or Individual Approach?—A Retrospective Analysis of Early Rehabilitation Protocols after Isolated Posterior Cruciate Ligament Reconstruction
por: Memmel, Clemens, et al.
Publicado: (2022)

Post-operative septic arthritis after arthroscopy: modern diagnostic and therapeutic concepts
por: Voss, Andreas, et al.
Publicado: (2021)

Spectrum of Tendon Pathologies: Triggers, Trails and End-State
por: Steinmann, Sara, et al.
Publicado: (2020)

Clavicle Elevation or Shoulder Girdle Depression in Acromioclavicular Joint Dislocation: A Radiological Investigation
por: Azar, Fady, et al.
Publicado: (2019)

Long-term patient-related quality of life after fracture-related infections of the long bones
por: Walter, Nike, et al.
Publicado: (2021)

Analyse des Trauma-Aufkommens in einer unfallchirurgischen Universitätsklinik während der SARS-CoV‑2-Pandemie
por: Popp, Daniel, et al.
Publicado: (2021)

Current Standards of Early Rehabilitation after Anterior Cruciate Ligament Reconstruction in German Speaking Countries—Differentiation Based on Tendon Graft and Concomitant Injuries
por: Memmel, Clemens, et al.
Publicado: (2022)

TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation
por: Pfeifer, Christian G., et al.
Publicado: (2019)

Editorial for Special Issue: Achilles Curse and Remedy: Tendon Diseases from Pathophysiology to Novel Therapeutic Approaches
por: Docheva, Denitsa
Publicado: (2020)

Erratum zu: PJI-TNM als neues Klassifikationssystem für Endoprotheseninfektionen: Eine Evaluation von 20 Fällen
por: Rupp, Markus, et al.
Publicado: (2021)

PJI-TNM als neues Klassifikationssystem für Endoprotheseninfektionen: Eine Evaluation von 20 Fällen
por: Rupp, Markus, et al.
Publicado: (2020)

Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection
por: Alagboso, Francisca I., et al.
Publicado: (2022)

Novel implant-free loop Tenodesis vs. simple Tenotomy of the long biceps tendon - a biomechanical investigation
por: Kerschbaum, Maximilian, et al.
Publicado: (2019)

Predictors of Mortality in Head-Preserving Treatment for Dislocated Proximal Humerus Fractures: A Retrospective Analysis of 522 Cases with a Minimum Follow-Up of 5 Years
por: Klute, Lisa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dm5j189oscfls1rc5u7bktu1or