Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines

Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted. Here, two GBM cell lines were treated with PAD2, PAD3 and PAD4 isozyme-specific inhibitors. Effects were assessed on extracellula...

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Detalles Bibliográficos
Autores principales: Uysal-Onganer, Pinar, MacLatchy, Amy, Mahmoud, Rayan, Kraev, Igor, Thompson, Paul R., Inal, Jameel M., Lange, Sigrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073130/
https://www.ncbi.nlm.nih.gov/pubmed/32098295
http://dx.doi.org/10.3390/ijms21041495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073130/
https://www.ncbi.nlm.nih.gov/pubmed/32098295
http://dx.doi.org/10.3390/ijms21041495

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