TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer

Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known to be mediated, in part, by stromal cells surrounding the tumor cells; however, the mechanisms underlying such a resistance phenotype remain...

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Detalles Bibliográficos
Autores principales: Yegodayev, Ksenia M., Novoplansky, Ofra, Golden, Artemiy, Prasad, Manu, Levin, Liron, Jagadeeshan, Sankar, Zorea, Jonathan, Dimitstein, Orr, Joshua, Ben-Zion, Cohen, Limor, Khrameeva, Ekaterina, Elkabets, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073231/
https://www.ncbi.nlm.nih.gov/pubmed/32028632
http://dx.doi.org/10.3390/cancers12020339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073231/
https://www.ncbi.nlm.nih.gov/pubmed/32028632
http://dx.doi.org/10.3390/cancers12020339

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