Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment

High‐grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that closely match the mutational profile and phenotype of the parental tumor. We found that Wnt pathway activation leads to gr...

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Detalles Bibliográficos
Autores principales: Hoffmann, Karen, Berger, Hilmar, Kulbe, Hagen, Thillainadarasan, Sukanija, Mollenkopf, Hans‐Joachim, Zemojtel, Tomasz, Taube, Eliane, Darb‐Esfahani, Silvia, Mangler, Mandy, Sehouli, Jalid, Chekerov, Radoslav, Braicu, Elena I, Meyer, Thomas F, Kessler, Mirjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073464/
https://www.ncbi.nlm.nih.gov/pubmed/32009247
http://dx.doi.org/10.15252/embj.2019104013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073464/
https://www.ncbi.nlm.nih.gov/pubmed/32009247
http://dx.doi.org/10.15252/embj.2019104013

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