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Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment
High‐grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that closely match the mutational profile and phenotype of the parental tumor. We found that Wnt pathway activation leads to gr...
Autores principales: | Hoffmann, Karen, Berger, Hilmar, Kulbe, Hagen, Thillainadarasan, Sukanija, Mollenkopf, Hans‐Joachim, Zemojtel, Tomasz, Taube, Eliane, Darb‐Esfahani, Silvia, Mangler, Mandy, Sehouli, Jalid, Chekerov, Radoslav, Braicu, Elena I, Meyer, Thomas F, Kessler, Mirjana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073464/ https://www.ncbi.nlm.nih.gov/pubmed/32009247 http://dx.doi.org/10.15252/embj.2019104013 |
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