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Embryo-Based Large Fragment Knock-in in Mammals: Why, How and What’s Next
Endonuclease-mediated genome editing technologies, most notably CRISPR/Cas9, have revolutionized animal genetics by allowing for precise genome editing directly through embryo manipulations. As endonuclease-mediated model generation became commonplace, large fragment knock-in remained one of the mos...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073597/ https://www.ncbi.nlm.nih.gov/pubmed/32013077 http://dx.doi.org/10.3390/genes11020140 |