Regioisomeric Family of Novel Fluorescent Substrates for SHIP2

[Image: see text] SHIP2 (SH2-domain containing inositol 5-phosphatase type 2) is a canonical 5-phosphatase, which, through its catalytic action on PtdInsP(3), regulates the PI3K/Akt pathway and metabolic action of insulin. It is a drug target, but there is limited evidence of inhibition of SHIP2 by...

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Detalles Bibliográficos
Autores principales: White, Gaye, Prior, Christopher, Mills, Stephen J., Baker, Kendall, Whitfield, Hayley, Riley, Andrew M., Oganesyan, Vasily S., Potter, Barry V. L., Brearley, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073872/
https://www.ncbi.nlm.nih.gov/pubmed/32184962
http://dx.doi.org/10.1021/acsmedchemlett.9b00368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073872/
https://www.ncbi.nlm.nih.gov/pubmed/32184962
http://dx.doi.org/10.1021/acsmedchemlett.9b00368

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