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The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA
Topoisomerase I in eukaryotic cells is an important regulator of DNA topology. Its catalytic function is to remove positive or negative superhelical tension by binding to duplex DNA, creating a reversible single-strand break, and finally religating the broken strand. Proper maintenance of DNA topolo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073998/ https://www.ncbi.nlm.nih.gov/pubmed/32059547 http://dx.doi.org/10.3390/genes11020193 |