Screening for Small Molecule Modulators of Trypanosoma brucei Hsp70 Chaperone Activity Based upon Alcyonarian Coral-Derived Natural Products

The Trypanosoma brucei Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis. This study evaluated a set of small molecules, inspired by the malonganenones and nuttingins,...

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Detalles Bibliográficos
Autores principales: Andreassend, Sarah K., Bentley, Stephen J., Blatch, Gregory L., Boshoff, Aileen, Keyzers, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074166/
https://www.ncbi.nlm.nih.gov/pubmed/32012664
http://dx.doi.org/10.3390/md18020081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074166/
https://www.ncbi.nlm.nih.gov/pubmed/32012664
http://dx.doi.org/10.3390/md18020081

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