Cargando…

Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane

A clarification method was proposed to ameliorate the technological quality of fruit juices by preserving bioactive compounds. This study evaluated the in vitro antioxidant and hypoglycemic activities and the in vivo effects of Punica granatum L. natural (NJ) and clarified (CJ) juice by polyvinylide...

Descripción completa

Detalles Bibliográficos
Autores principales: Morittu, Valeria Maria, Mastellone, Vincenzo, Tundis, Rosa, Loizzo, Monica Rosa, Tudisco, Raffaella, Figoli, Alberto, Cassano, Alfredo, Musco, Nadia, Britti, Domenico, Infascelli, Federico, Lombardi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074394/
https://www.ncbi.nlm.nih.gov/pubmed/32102311
http://dx.doi.org/10.3390/foods9020242
_version_ 1783506823131693056
author Morittu, Valeria Maria
Mastellone, Vincenzo
Tundis, Rosa
Loizzo, Monica Rosa
Tudisco, Raffaella
Figoli, Alberto
Cassano, Alfredo
Musco, Nadia
Britti, Domenico
Infascelli, Federico
Lombardi, Pietro
author_facet Morittu, Valeria Maria
Mastellone, Vincenzo
Tundis, Rosa
Loizzo, Monica Rosa
Tudisco, Raffaella
Figoli, Alberto
Cassano, Alfredo
Musco, Nadia
Britti, Domenico
Infascelli, Federico
Lombardi, Pietro
author_sort Morittu, Valeria Maria
collection PubMed
description A clarification method was proposed to ameliorate the technological quality of fruit juices by preserving bioactive compounds. This study evaluated the in vitro antioxidant and hypoglycemic activities and the in vivo effects of Punica granatum L. natural (NJ) and clarified (CJ) juice by polyvinylidene fluoride (PVDF) hollow fiber membrane. CJ was more active as an antioxidant and as a α-glucosidase inhibitor than NJ. Mice were orally gavaged with water (Control), NJ, and CJ for 28 days. NJ group showed significant decrease of alanine aminotransferase, aspartate amino transferase, and creatine-phosphokinase. CJ administration was associated with urea, creatine-phosphokinase, and triglycerides values significantly lower with respect to the control. Oxidative status was ameliorated with CJ administration, showing a reactive oxygen metabolites (d-ROMs) reduction of 32% and a biological antioxidant potential (BAP) boosting of 23% compared to the control, whereas NJ did not show a similar effect. Results confirmed the beneficial properties of pomegranate juice, showing that membrane clarification may enhance such effects in terms of antioxidant activity.
format Online
Article
Text
id pubmed-7074394
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70743942020-03-20 Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane Morittu, Valeria Maria Mastellone, Vincenzo Tundis, Rosa Loizzo, Monica Rosa Tudisco, Raffaella Figoli, Alberto Cassano, Alfredo Musco, Nadia Britti, Domenico Infascelli, Federico Lombardi, Pietro Foods Article A clarification method was proposed to ameliorate the technological quality of fruit juices by preserving bioactive compounds. This study evaluated the in vitro antioxidant and hypoglycemic activities and the in vivo effects of Punica granatum L. natural (NJ) and clarified (CJ) juice by polyvinylidene fluoride (PVDF) hollow fiber membrane. CJ was more active as an antioxidant and as a α-glucosidase inhibitor than NJ. Mice were orally gavaged with water (Control), NJ, and CJ for 28 days. NJ group showed significant decrease of alanine aminotransferase, aspartate amino transferase, and creatine-phosphokinase. CJ administration was associated with urea, creatine-phosphokinase, and triglycerides values significantly lower with respect to the control. Oxidative status was ameliorated with CJ administration, showing a reactive oxygen metabolites (d-ROMs) reduction of 32% and a biological antioxidant potential (BAP) boosting of 23% compared to the control, whereas NJ did not show a similar effect. Results confirmed the beneficial properties of pomegranate juice, showing that membrane clarification may enhance such effects in terms of antioxidant activity. MDPI 2020-02-24 /pmc/articles/PMC7074394/ /pubmed/32102311 http://dx.doi.org/10.3390/foods9020242 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morittu, Valeria Maria
Mastellone, Vincenzo
Tundis, Rosa
Loizzo, Monica Rosa
Tudisco, Raffaella
Figoli, Alberto
Cassano, Alfredo
Musco, Nadia
Britti, Domenico
Infascelli, Federico
Lombardi, Pietro
Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title_full Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title_fullStr Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title_full_unstemmed Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title_short Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane
title_sort antioxidant, biochemical, and in-life effects of punica granatum l. natural juice vs. clarified juice by polyvinylidene fluoride membrane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074394/
https://www.ncbi.nlm.nih.gov/pubmed/32102311
http://dx.doi.org/10.3390/foods9020242
work_keys_str_mv AT morittuvaleriamaria antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT mastellonevincenzo antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT tundisrosa antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT loizzomonicarosa antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT tudiscoraffaella antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT figolialberto antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT cassanoalfredo antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT musconadia antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT brittidomenico antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT infascellifederico antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane
AT lombardipietro antioxidantbiochemicalandinlifeeffectsofpunicagranatumlnaturaljuicevsclarifiedjuicebypolyvinylidenefluoridemembrane