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Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury

Infection with avian influenza A H5N1 virus results in acute lung injury (ALI) and has a high mortality rate (52.79%) because there are limited therapies available for treatment. Drug repositioning is an economical approach to drug discovery. We developed a method for drug repositioning based on hig...

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Detalles Bibliográficos
Autores principales: Huang, Fengming, Zhang, Cong, Liu, Qiang, Zhao, Yan, Zhang, Yuqing, Qin, Yuhao, Li, Xiao, Li, Chang, Zhou, Congzhao, Jin, Ningyi, Jiang, Chengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075543/
https://www.ncbi.nlm.nih.gov/pubmed/32176725
http://dx.doi.org/10.1371/journal.ppat.1008341