ARL13B regulates Sonic hedgehog signaling from outside primary cilia

ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and showed it retains all know...

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Detalles Bibliográficos
Autores principales: Gigante, Eduardo D, Taylor, Megan R, Ivanova, Anna A, Kahn, Richard A, Caspary, Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075693/
https://www.ncbi.nlm.nih.gov/pubmed/32129762
http://dx.doi.org/10.7554/eLife.50434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075693/
https://www.ncbi.nlm.nih.gov/pubmed/32129762
http://dx.doi.org/10.7554/eLife.50434

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