Cargando…

ARL13B regulates Sonic hedgehog signaling from outside primary cilia

ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and showed it retains all know...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gigante, Eduardo D, Taylor, Megan R, Ivanova, Anna A, Kahn, Richard A, Caspary, Tamara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075693/ https://www.ncbi.nlm.nih.gov/pubmed/32129762 http://dx.doi.org/10.7554/eLife.50434

Ejemplares similares

Arl13b regulates Shh signaling from both inside and outside the cilium
por: Mariani, Laura E., et al.
Publicado: (2016)

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
por: Dhekne, Herschel S, et al.
Publicado: (2018)

The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
por: Ferent, Julien, et al.
Publicado: (2019)

Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish
por: Song, Ping, et al.
Publicado: (2016)

Arl13b-regulated activities of primary cilia are essential for the formation of the polarized radial glial scaffold
por: Higginbotham, Holden, et al.
Publicado: (2013)

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse
por: Van Sciver, Robert E., et al.
Publicado: (2023)

Cleavage activates Dispatched for Sonic Hedgehog ligand release
por: Stewart, Daniel P, et al.
Publicado: (2018)

Sonic Hedgehog Signaling in Limb Development
por: Tickle, Cheryll, et al.
Publicado: (2017)

Ciliary ARL13B prevents obesity in mice
por: Terry, Tiffany T., et al.
Publicado: (2023)

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria
por: Thorpe, Stephen D., et al.
Publicado: (2017)

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
por: Khan, Shahzad S, et al.
Publicado: (2021)

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia
por: Shi, Ping, et al.
Publicado: (2023)

ARL-13 SUMO wrestles receptors into cilia
por: Short, Ben
Publicado: (2012)

Sonic Hedgehog Signaling in Cerebellar Development and Cancer
por: Wang, Wanchen, et al.
Publicado: (2022)

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
por: Brooks, Eric R, et al.
Publicado: (2020)

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins
por: Larkins, Christine E., et al.
Publicado: (2011)

Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in Salamanders
por: Purushothaman, Sruthi, et al.
Publicado: (2022)

Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
por: Vorobyeva, Anna G., et al.
Publicado: (2018)

Arl13b influences cilia length in the zebrafish Kupffer’s vesicle
por: Pintado, P, et al.
Publicado: (2013)

Arl13b and the exocyst interact synergistically in ciliogenesis
por: Seixas, Cecília, et al.
Publicado: (2016)

Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway
por: Cao, Wanshuang, et al.
Publicado: (2021)

Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog Signaling
por: Cui, Wei, et al.
Publicado: (2020)

Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx
por: Tabler, Jacqueline M, et al.
Publicado: (2017)

Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development
por: Sun, Miranda R., et al.
Publicado: (2020)

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception
por: Yue, Shen, et al.
Publicado: (2014)

Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response
por: Piotrowska-Nitsche, Karolina, et al.
Publicado: (2012)

Loss of ARL13 impedes BBSome-dependent cargo export from Chlamydomonas cilia
por: Dai, Jin, et al.
Publicado: (2022)

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
por: Hall, Eric T, et al.
Publicado: (2021)

SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors
por: Umberger, Patricia A., et al.
Publicado: (2021)

ERICH3 in Primary Cilia Regulates Cilium Formation and the Localisations of Ciliary Transport and Sonic Hedgehog Signaling Proteins
por: Alsolami, Mona, et al.
Publicado: (2019)

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling
por: Shi, Hairong, et al.
Publicado: (2022)

Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets
por: Choe, Youngshik, et al.
Publicado: (2015)

Inactivation of Sonic Hedgehog Signaling and Polydactyly in Limbs of Hereditary Multiple Malformation, a Novel Type of Talpid Mutant
por: Matsubara, Yoshiyuki, et al.
Publicado: (2016)

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE
por: Sandoval, Lisette, et al.
Publicado: (2022)

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex
por: Shi, Meng, et al.
Publicado: (2022)

The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations
por: Yang, Feng, et al.
Publicado: (2021)

Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage
por: Feng, Meng, et al.
Publicado: (2021)

Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation
por: Senatore, Emanuela, et al.
Publicado: (2022)

Editorial: Signaling by primary cilia in development and disease
por: Kim, Sung-Eun, et al.
Publicado: (2023)

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons
por: Bowie, Emily, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3pmli71dovvafp67hdr42a30vk