The radiosensitizer Onalespib increases complete remission in (177)Lu-DOTATATE-treated mice bearing neuroendocrine tumor xenografts

PURPOSE: (177)Lu-DOTATATE targeting the somatostatin receptor (SSTR) is utilized for treatment of neuroendocrine tumors (NETs). Onalespib, a heat shock protein 90 (HSP90) inhibitor, has demonstrated radiosensitizing properties and may thus enhance the effect of (177)Lu-DOTATATE. Consequently, the ai...

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Detalles Bibliográficos
Autores principales: Lundsten, Sara, Spiegelberg, Diana, Raval, Nakul R., Nestor, Marika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075859/
https://www.ncbi.nlm.nih.gov/pubmed/31912256
http://dx.doi.org/10.1007/s00259-019-04673-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075859/
https://www.ncbi.nlm.nih.gov/pubmed/31912256
http://dx.doi.org/10.1007/s00259-019-04673-1

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