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Seeking high-priority mutations enabling successful antibody-breeding: systematic analysis of a mutant that gained over 100-fold enhanced affinity
“Antibody-breeding” has provided therapeutic/diagnostic antibody mutants with greater performance than native antibodies. Typically, random point mutations are introduced into the V(H) and V(L) domains of parent antibodies to generate diverse libraries of single-chain Fv fragments (scFvs), from whic...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075871/ https://www.ncbi.nlm.nih.gov/pubmed/32179767 http://dx.doi.org/10.1038/s41598-020-61529-7 |