Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 (Kmt2a) gene generate powerful oncogenic fusion protei...

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Detalles Bibliográficos
Autores principales: Basilico, Silvia, Wang, Xiaonan, Kennedy, Alison, Tzelepis, Konstantinos, Giotopoulos, George, Kinston, Sarah J., Quiros, Pedro M., Wong, Kim, Adams, David J., Carnevalli, Larissa S., Huntly, Brian J. P., Vassiliou, George S., Calero-Nieto, Fernando J., Göttgens, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075888/
https://www.ncbi.nlm.nih.gov/pubmed/32179751
http://dx.doi.org/10.1038/s41467-020-15220-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075888/
https://www.ncbi.nlm.nih.gov/pubmed/32179751
http://dx.doi.org/10.1038/s41467-020-15220-0

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