Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90

The heat shock protein 90 (Hsp90) is a molecular chaperone that employs the free energy of ATP hydrolysis to control the folding and activation of several client proteins in the eukaryotic cell. To elucidate how the local ATPase reaction in the active site couples to the global conformational dynami...

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Detalles Bibliográficos
Autores principales: Mader, Sophie L., Lopez, Abraham, Lawatscheck, Jannis, Luo, Qi, Rutz, Daniel A., Gamiz-Hernandez, Ana P., Sattler, Michael, Buchner, Johannes, Kaila, Ville R. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075974/
https://www.ncbi.nlm.nih.gov/pubmed/32179743
http://dx.doi.org/10.1038/s41467-020-15050-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075974/
https://www.ncbi.nlm.nih.gov/pubmed/32179743
http://dx.doi.org/10.1038/s41467-020-15050-0

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