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Suprachiasmatic lesions restore object recognition in down syndrome model mice

The Ts65Dn mouse is a well-studied model of trisomy 21, Down syndrome. This mouse strain has severe learning disability as measured by several rodent learning tests that depend on hippocampal spatial memory function. Hippocampal long-term potentiation (LTP) is deficient in these mice. Short-term dai...

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Detalles Bibliográficos
Autores principales: Chuluun, Bayarsaikhan, Pittaras, Elsa, Hong, Hyunseung, Fisher, Nathan, Colas, Damien, Ruby, Norman F., Heller, H. Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075983/
https://www.ncbi.nlm.nih.gov/pubmed/32195448
http://dx.doi.org/10.1016/j.nbscr.2020.100049