Effects of senataxin and RNA exosome on B-cell chromosomal integrity

Loss of function of senataxin (SETX), a bona-fide RNA/DNA helicase, is associated with neuronal degeneration leading to Ataxia and Ocular Apraxia (AOA) in human patients. SETX is proposed to promote transcription termination, DNA replication, DNA repair, and to unwind deleterious RNA:DNA hybrids in...

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Detalles Bibliográficos
Autores principales: Kazadi, David, Lim, Junghyun, Rothschild, Gerson, Grinstein, Veronika, Laffleur, Brice, Becherel, Olivier, Lavin, Martin J., Basu, Uttiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075999/
https://www.ncbi.nlm.nih.gov/pubmed/32195383
http://dx.doi.org/10.1016/j.heliyon.2020.e03442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075999/
https://www.ncbi.nlm.nih.gov/pubmed/32195383
http://dx.doi.org/10.1016/j.heliyon.2020.e03442

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