Cargando…

Effects of senataxin and RNA exosome on B-cell chromosomal integrity

Loss of function of senataxin (SETX), a bona-fide RNA/DNA helicase, is associated with neuronal degeneration leading to Ataxia and Ocular Apraxia (AOA) in human patients. SETX is proposed to promote transcription termination, DNA replication, DNA repair, and to unwind deleterious RNA:DNA hybrids in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kazadi, David, Lim, Junghyun, Rothschild, Gerson, Grinstein, Veronika, Laffleur, Brice, Becherel, Olivier, Lavin, Martin J., Basu, Uttiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075999/ https://www.ncbi.nlm.nih.gov/pubmed/32195383 http://dx.doi.org/10.1016/j.heliyon.2020.e03442

Ejemplares similares

Senataxin protects the genome: Implications for neurodegeneration and other abnormalities
por: Lavin, Martin F., et al.
Publicado: (2013)

Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
por: Yeo, Abrey J, et al.
Publicado: (2015)

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing
por: Becherel, Olivier J., et al.
Publicado: (2013)

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage
por: Suraweera, Amila, et al.
Publicado: (2007)

The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
por: Miller, Matthew S., et al.
Publicado: (2015)

Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
por: Sun, Jianbo, et al.
Publicado: (2013)

Ubiquitination Events That Regulate Recombination of Immunoglobulin Loci Gene Segments
por: Chao, Jaime, et al.
Publicado: (2014)

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes
por: Alzu, Amaya, et al.
Publicado: (2012)

Regulating autophagy: a novel role for SETX (Senataxin)
por: Richard, Patricia, et al.
Publicado: (2021)

Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis
por: Gatti, Veronica, et al.
Publicado: (2023)

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
por: Hasanova, Zdenka, et al.
Publicado: (2023)

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
por: Richard, Patricia, et al.
Publicado: (2013)

USP11 controls R-loops by regulating senataxin proteostasis
por: Jurga, Mateusz, et al.
Publicado: (2021)

Expression and Function of Tetraspanins and Their Interacting Partners in B Cells
por: Zou, Fagui, et al.
Publicado: (2018)

Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide
por: Bennett, Craig L., et al.
Publicado: (2013)

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
por: Cohen, Sarah, et al.
Publicado: (2018)

Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes
por: Dézé, Ophélie, et al.
Publicado: (2023)

Clinical and Molecular Aspects of Senataxin Mutations in Amyotrophic Lateral Sclerosis 4
por: Grunseich, Christopher, et al.
Publicado: (2020)

E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells
por: Sun, Jianbo, et al.
Publicado: (2013)

Hereditary Ataxia with a Novel Mutation in the Senataxin Gene: A Case Report
por: Moghanloo, Ehsan, et al.
Publicado: (2019)

Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging
por: Homer, Hayden A.
Publicado: (2021)

Aberrant Splicing of the Senataxin Gene in a Patient with Ataxia with Oculomotor Apraxia Type 2
por: Fogel, Brent L., et al.
Publicado: (2009)

Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
por: Kannan, Annapoorna, et al.
Publicado: (2022)

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
por: Skourti-Stathaki, Konstantina, et al.
Publicado: (2011)

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin
por: Brustel, Julien, et al.
Publicado: (2018)

SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease
por: Bennett, Craig L., et al.
Publicado: (2021)

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
por: Andrews, Alex M., et al.
Publicado: (2018)

Self-control for IgE production
por: Laffleur, Brice, et al.
Publicado: (2015)

B Cell Intrinsic Mechanisms Constraining IgE Memory
por: Laffleur, Brice, et al.
Publicado: (2017)

Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy
por: Kannan, Annapoorna, et al.
Publicado: (2018)

ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes
por: Gatti, Veronica, et al.
Publicado: (2022)

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination
por: Zhao, Hongchang, et al.
Publicado: (2022)

RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
por: Fraga de Andrade, Isabela, et al.
Publicado: (2022)

Identification of novel senataxin mutations in Chinese patients with autosomal recessive cerebellar ataxias by targeted next-generation sequencing
por: Lu, Cong, et al.
Publicado: (2016)

Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis
por: Subramanian, Goutham Narayanan, et al.
Publicado: (2020)

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells
por: Skamagki, Maria, et al.
Publicado: (2017)

A novel c.5308_5311delGAGA mutation in Senataxin in a Cypriot family with an autosomal recessive cerebellar ataxia
por: Nicolaou, Paschalis, et al.
Publicado: (2008)

Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly
por: Bennett, Craig L., et al.
Publicado: (2020)

Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux
por: Casey, Aaron E., et al.
Publicado: (2022)

AID-induced remodeling of immunoglobulin genes and B cell fate
por: Laffleur, Brice, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_20i6c9l4f2q66cjis6slv1kg3l