Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells

Owing to the involvement of cyclooxygenase-2 (COX-2) in carcinogenesis, COX-2-selective inhibitors are increasingly studied for their potential cytotoxic properties. Moreover, the incorporation of carboranes in structures of established anti-inflammatory drugs can improve the potency and metabolic s...

Descripción completa

Detalles Bibliográficos
Autores principales: Buzharevski, Antonio, Paskaš, Svetlana, Sárosi, Menyhárt-Botond, Laube, Markus, Lönnecke, Peter, Neumann, Wilma, Murganić, Blagoje, Mijatović, Sanja, Maksimović-Ivanić, Danijelа, Pietzsch, Jens, Hey-Hawkins, Evamarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076013/
https://www.ncbi.nlm.nih.gov/pubmed/32179835
http://dx.doi.org/10.1038/s41598-020-59059-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076013/
https://www.ncbi.nlm.nih.gov/pubmed/32179835
http://dx.doi.org/10.1038/s41598-020-59059-3

Ejemplares similares