Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein

Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases. Therefore, APP processing has been a target in...

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Detalles Bibliográficos
Autores principales: Seki, Tsuneyoshi, Kanagawa, Motoi, Kobayashi, Kazuhiro, Kowa, Hisatomo, Yahata, Naoki, Maruyama, Kei, Iwata, Nobuhisa, Inoue, Haruhisa, Toda, Tatsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076203/
https://www.ncbi.nlm.nih.gov/pubmed/31996371
http://dx.doi.org/10.1074/jbc.RA119.008703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076203/
https://www.ncbi.nlm.nih.gov/pubmed/31996371
http://dx.doi.org/10.1074/jbc.RA119.008703

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