Cargando…

Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein

Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases. Therefore, APP processing has been a target in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seki, Tsuneyoshi, Kanagawa, Motoi, Kobayashi, Kazuhiro, Kowa, Hisatomo, Yahata, Naoki, Maruyama, Kei, Iwata, Nobuhisa, Inoue, Haruhisa, Toda, Tatsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076203/ https://www.ncbi.nlm.nih.gov/pubmed/31996371 http://dx.doi.org/10.1074/jbc.RA119.008703

Ejemplares similares

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline
por: Uchida, Kazuhiko, et al.
Publicado: (2015)

Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's
por: Tomita, Taisuke, et al.
Publicado: (2011)

Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals
por: Fandos, Noelia, et al.
Publicado: (2017)

Targeting apolipoprotein E and N-terminal amyloid β-protein precursor interaction improves cognition and reduces amyloid pathology in Alzheimer’s mice
por: Sawmiller, Darrell, et al.
Publicado: (2023)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo
por: Fluharty, Brian R., et al.
Publicado: (2013)

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells
por: Kokawa, Asuka, et al.
Publicado: (2015)

β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes
por: Jakhria, Toral, et al.
Publicado: (2014)

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
por: Portelius, Erik, et al.
Publicado: (2014)

Expanding the Repertoire of Amyloid Polymorphs by Co-polymerization of Related Protein Precursors
por: Sarell, Claire J., et al.
Publicado: (2013)

Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein
por: Chun, Yoon Sun, et al.
Publicado: (2019)

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
por: Willén, Katarina, et al.
Publicado: (2017)

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products
por: van Husen, Lea S., et al.
Publicado: (2019)

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†
por: Zhou, Lujia, et al.
Publicado: (2011)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90
por: Noorani, Arshad Ali, et al.
Publicado: (2021)

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
por: Chyung, Abraham S.C., et al.
Publicado: (1997)

Intracellular Cleavage of Amyloid β by a Viral Protease NIa Prevents Amyloid β-Mediated Cytotoxicity
por: Shin, Baehyun, et al.
Publicado: (2014)

Amyloid precursor protein modulates β-catenin degradation
por: Chen, Yuzhi, et al.
Publicado: (2007)

β-Amyloid precursor protein (APP) and the human diseases
por: Nguyen, Khue Vu
Publicado: (2019)

Apple Procyanidins Suppress Amyloid β-Protein Aggregation
por: Toda, Toshihiko, et al.
Publicado: (2011)

Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
por: Trysberg, Estelle, et al.
Publicado: (2004)

Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin
por: Stemmer, Nina, et al.
Publicado: (2013)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
por: Pluta, Ryszard, et al.
Publicado: (2012)

Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production
por: Khan, Ayesha, et al.
Publicado: (2023)

Selection of mutant µplasmin for amyloid-β cleavage in vivo
por: Yang, Dongying, et al.
Publicado: (2020)

The global Alzheimer's Association round robin study on plasma amyloid β methods
por: Pannee, Josef, et al.
Publicado: (2021)

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
por: Hicks, David A., et al.
Publicado: (2020)

Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2013)

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
por: Edgar, James R., et al.
Publicado: (2015)

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
por: Serneels, Lutgarde, et al.
Publicado: (2020)

The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation
por: Poulsen, Ebbe Toftgaard, et al.
Publicado: (2019)

Pharmacological targeting of the β-amyloid precursor protein intracellular domain
por: Branca, Caterina, et al.
Publicado: (2014)

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
por: Kamikubo, Yuji, et al.
Publicado: (2023)

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
por: Neniskyte, Urte, et al.
Publicado: (2011)

Extracellular matrix components modulate different stages in β(2)-microglobulin amyloid formation
por: Benseny-Cases, Núria, et al.
Publicado: (2019)

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
por: Lautenschläger, Janin, et al.
Publicado: (2020)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_kme1t47dq83s9ers3bjfvhoaoe