A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H(2)O(2) and Is the Target of a Small Molecule

Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue is conserved in the fission yeast Schizosaccharomyces pombe MAPKK Wis1, which belongs to the H(2)O(2)-responsive M...

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Detalles Bibliográficos
Autores principales: Sjölander, Johanna J., Tarczykowska, Agata, Picazo, Cecilia, Cossio, Itziar, Redwan, Itedale Namro, Gao, Chunxia, Solano, Carlos, Toledano, Michel B., Grøtli, Morten, Molin, Mikael, Sunnerhagen, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076255/
https://www.ncbi.nlm.nih.gov/pubmed/31932483
http://dx.doi.org/10.1128/MCB.00346-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076255/
https://www.ncbi.nlm.nih.gov/pubmed/31932483
http://dx.doi.org/10.1128/MCB.00346-19

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