Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy

Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe peripheral neuropathy but confers high anticancer effica...

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Detalles Bibliográficos
Autores principales: Kobuchi, Shinji, Shimizu, Risa, Ito, Yukako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076355/
https://www.ncbi.nlm.nih.gov/pubmed/32028733
http://dx.doi.org/10.3390/pharmaceutics12020125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076355/
https://www.ncbi.nlm.nih.gov/pubmed/32028733
http://dx.doi.org/10.3390/pharmaceutics12020125

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