The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Permeation enhancers like sodium dodecyl sulfate (SDS) and caprate increase the intestinal permeability of small model peptide compounds, such as enalaprilat (349 Da). However, their effects remain to be investigated for larger low-permeability peptide drugs, such as hexarelin (887 Da). The objectiv...

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Detalles Bibliográficos
Autores principales: Dahlgren, David, Sjöblom, Markus, Hedeland, Mikael, Lennernäs, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076382/
https://www.ncbi.nlm.nih.gov/pubmed/31991924
http://dx.doi.org/10.3390/pharmaceutics12020099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076382/
https://www.ncbi.nlm.nih.gov/pubmed/31991924
http://dx.doi.org/10.3390/pharmaceutics12020099

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