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Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo
This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)—combined wit...
Autores principales: | Xi, Ziyue, Zhang, Wei, Fei, Yali, Cui, Mingshu, Xie, Luyao, Chen, Lu, Xu, Lu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076385/ https://www.ncbi.nlm.nih.gov/pubmed/32050600 http://dx.doi.org/10.3390/pharmaceutics12020144 |
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