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Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric dr...

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Detalles Bibliográficos
Autores principales: Janisova, Larisa, Gruzinov, Andrey, Zaborova, Olga V., Velychkivska, Nadiia, Vaněk, Ondřej, Chytil, Petr, Etrych, Tomáš, Janoušková, Olga, Zhang, Xiaohan, Blanchet, Clement, Papadakis, Christine M., Svergun, Dmitri I., Filippov, Sergey K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076460/
https://www.ncbi.nlm.nih.gov/pubmed/32013056
http://dx.doi.org/10.3390/pharmaceutics12020106