Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery

The retinal pigment epithelial (RPE) cell monolayer forms the outer blood–retinal barrier and has a crucial role in ocular pharmacokinetics. Although several RPE cell models are available, there have been no systematic comparisons of their barrier properties with respect to drug permeability. We com...

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Detalles Bibliográficos
Autores principales: Hellinen, Laura, Hongisto, Heidi, Ramsay, Eva, Kaarniranta, Kai, Vellonen, Kati-Sisko, Skottman, Heli, Ruponen, Marika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076505/
https://www.ncbi.nlm.nih.gov/pubmed/32093035
http://dx.doi.org/10.3390/pharmaceutics12020176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076505/
https://www.ncbi.nlm.nih.gov/pubmed/32093035
http://dx.doi.org/10.3390/pharmaceutics12020176

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