Cargando…

Pharmacokinetics and Intestinal Metabolism of Compound K in Rats and Mice

We aimed to investigate the plasma concentration, tissue distribution, and elimination of compound K following the intravenous administration of compound K (2 mg/kg) in rats and mice. The plasma concentrations of compound K in mice were much higher (about five-fold) than those in rats. In both rats...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeon, Ji-Hyeon, Kang, Bitna, Lee, Sowon, Jin, Sojeong, Choi, Min-Koo, Song, Im-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076525/ https://www.ncbi.nlm.nih.gov/pubmed/32028741 http://dx.doi.org/10.3390/pharmaceutics12020129

Ejemplares similares

Enhanced Intestinal Permeability and Plasma Concentration of Metformin in Rats by the Repeated Administration of Red Ginseng Extract
por: Jin, Sojeong, et al.
Publicado: (2019)

Detection of 13 Ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20(S)-Protopanaxadiol, and 20(S)-Protopanaxatriol) in Human Plasma and Application of the Analytical Method to Human Pharmacokinetic Studies Following Two Week-Repeated Administration of Red Ginseng Extract
por: Jin, Sojeong, et al.
Publicado: (2019)

Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings
por: Choi, Min-Koo, et al.
Publicado: (2020)

Pharmacokinetics and Tissue Distribution of Enavogliflozin in Mice and Rats
por: Pang, Minyeong, et al.
Publicado: (2022)

Herb–Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats
por: Jeon, Ji-Hyeon, et al.
Publicado: (2020)

Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation
por: Kwon, Mihwa, et al.
Publicado: (2020)

Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice
por: Jeon, Ji-Hyeon, et al.
Publicado: (2021)

Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract
por: Han, You Jin, et al.
Publicado: (2019)

Effect of Red Ginseng Extract on the Pharmacokinetics and Efficacy of Metformin in Streptozotocin-Induced Diabetic Rats
por: Nam, So Jeong, et al.
Publicado: (2018)

Effects of Red Ginseng Extract on the Pharmacokinetics and Elimination of Methotrexate via Mrp2 Regulation
por: Lee, Sowon, et al.
Publicado: (2018)

The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions
por: Kwon, Mihwa, et al.
Publicado: (2020)

Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats
por: Choi, Min-Koo, et al.
Publicado: (2017)

Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract
por: Jeon, So-Yeon, et al.
Publicado: (2022)

Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions
por: Choi, Min-Koo, et al.
Publicado: (2021)

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity
por: Song, Im-Sook, et al.
Publicado: (2021)

Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting
por: Lee, Jihoon, et al.
Publicado: (2023)

Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
por: Choi, Young A., et al.
Publicado: (2018)

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
por: Lee, Ji Sang, et al.
Publicado: (2019)

Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid
por: Kang, Yun Ju, et al.
Publicado: (2021)

Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin
por: Choi, Min-Koo, et al.
Publicado: (2020)

Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa
por: Hwang, Hyeon-Ji, et al.
Publicado: (2021)

Concomitant Administration of Red Ginseng Extract with Lactic Acid Bacteria Increases the Plasma Concentration of Deglycosylated Ginsenosides in Healthy Human Subjects
por: Jeon, Ji-Hyeon, et al.
Publicado: (2022)

Pharmacokinetics and Metabolism of Acetyl Triethyl Citrate, a Water-Soluble Plasticizer for Pharmaceutical Polymers in Rats
por: Kim, Hyeon, et al.
Publicado: (2019)

Pharmacokinetics of memantine in rats and mice
por: Beconi, Maria G., et al.
Publicado: (2012)

Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats
por: Lee, Ji-Sang, et al.
Publicado: (2021)

Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats
por: Feng, Xinchi, et al.
Publicado: (2014)

Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats
por: Zhou, Jinping, et al.
Publicado: (2022)

Improved Hygroscopicity and Bioavailability of Solid Dispersion of Red Ginseng Extract with Silicon Dioxide
por: Jin, Sojeong, et al.
Publicado: (2021)

Effects of Intestinal Microbiota on Pharmacokinetics of Crocin and Crocetin in Male Sprague-Dawley Rats
por: Shakya, Rajina, et al.
Publicado: (2020)

Inhalation pharmacokinetics of isoprene in rats and mice.
por: Peter, H, et al.
Publicado: (1990)

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling
por: Kim, Jaeyong, et al.
Publicado: (2018)

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with (89)Zr Radioisotope in Mice and Rats
por: Choi, Hojun, et al.
Publicado: (2022)

Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng
por: Kim, Jeon-Kyung, et al.
Publicado: (2020)

Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities
por: Sharma, Anshul, et al.
Publicado: (2020)

Polymorphic Characterization, Pharmacokinetics, and Anti-Inflammatory Activity of Ginsenoside Compound K Polymorphs
por: Kuang, Yun-Yan, et al.
Publicado: (2021)

Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans
por: Bae, Soo Hyeon, et al.
Publicado: (2018)

Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats
por: Song, Yoo-Kyung, et al.
Publicado: (2021)

Inhibitory Effect of AB-PINACA, Indazole Carboxamide Synthetic Cannabinoid, on Human Major Drug-Metabolizing Enzymes and Transporters
por: Park, Eun Jeong, et al.
Publicado: (2020)

Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers
por: Yoshida, Kosuke, et al.
Publicado: (2021)

Pharmacokinetic Interaction of Chrysin with Caffeine in Rats
por: Noh, Keumhan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l0muotvgo5tmrteudvjt7i2ba5