Pulmonary Metabolism of Substrates for Key Drug-Metabolizing Enzymes by Human Alveolar Type II Cells, Human and Rat Lung Microsomes, and the Isolated Perfused Rat Lung Model

Significant pulmonary metabolism of inhaled drugs could have drug safety implications or influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are often employed. Here, we have determined if rat and human lung microsomes are fit for purpose or whether it is better to...

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Detalles Bibliográficos
Autores principales: Rubin, Katarina, Ewing, Pär, Bäckström, Erica, Abrahamsson, Anna, Bonn, Britta, Kamata, Satoshi, Grime, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076545/
https://www.ncbi.nlm.nih.gov/pubmed/32024122
http://dx.doi.org/10.3390/pharmaceutics12020117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076545/
https://www.ncbi.nlm.nih.gov/pubmed/32024122
http://dx.doi.org/10.3390/pharmaceutics12020117

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