Cargando…
Pulmonary Metabolism of Substrates for Key Drug-Metabolizing Enzymes by Human Alveolar Type II Cells, Human and Rat Lung Microsomes, and the Isolated Perfused Rat Lung Model
Significant pulmonary metabolism of inhaled drugs could have drug safety implications or influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are often employed. Here, we have determined if rat and human lung microsomes are fit for purpose or whether it is better to...
Autores principales: | Rubin, Katarina, Ewing, Pär, Bäckström, Erica, Abrahamsson, Anna, Bonn, Britta, Kamata, Satoshi, Grime, Ken |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076545/ https://www.ncbi.nlm.nih.gov/pubmed/32024122 http://dx.doi.org/10.3390/pharmaceutics12020117 |
Ejemplares similares
-
The metabolism of gelsevirine in human, pig, goat and rat liver microsomes
por: Zhang, Hua‐Hai, et al.
Publicado: (2021) -
Human and rat microsomal metabolites of N-tert-butoxycarbonylmethamphetamine and its urinary metabolites in rat
por: Kakehashi, Hidenao, et al.
Publicado: (2021) -
Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.
por: Coleman, S, et al.
Publicado: (2000) -
The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes
por: Li, Feng, et al.
Publicado: (2018) -
Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes
por: Ma, Zhongnv, et al.
Publicado: (2016)