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Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity

Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% w/v in ambient conditions. This can happen at any time, whether on...

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Detalles Bibliográficos
Autores principales: Kavanagh, Oisín, Hogan, Fiona, Murphy, Caoimhe, Croker, Denise, Walker, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076636/
https://www.ncbi.nlm.nih.gov/pubmed/32098214
http://dx.doi.org/10.3390/pharmaceutics12020187