The Q(i) Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

[Image: see text] Available treatments for Chagas’ disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of phenotypically active compounds i...

Descripción completa

Detalles Bibliográficos
Autores principales: Wall, Richard J., Carvalho, Sandra, Milne, Rachel, Bueren-Calabuig, Juan A., Moniz, Sonia, Cantizani-Perez, Juan, MacLean, Lorna, Kessler, Albane, Cotillo, Ignacio, Sastry, Lalitha, Manthri, Sujatha, Patterson, Stephen, Zuccotto, Fabio, Thompson, Stephen, Martin, Julio, Marco, Maria, Miles, Timothy J., De Rycker, Manu, Thomas, Michael G., Fairlamb, Alan H., Gilbert, Ian H., Wyllie, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076694/
https://www.ncbi.nlm.nih.gov/pubmed/31967783
http://dx.doi.org/10.1021/acsinfecdis.9b00426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076694/
https://www.ncbi.nlm.nih.gov/pubmed/31967783
http://dx.doi.org/10.1021/acsinfecdis.9b00426

Ejemplares similares