Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

The phospholipase A(2) (PLA(2)) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA(2) activity of a wide variety of snake venoms. In this study, the ability of these two forms of Varespladib to halt or delay lethality of potent neurotoxic...

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Detalles Bibliográficos
Autores principales: Gutiérrez, José María, Lewin, Matthew R., Williams, David. J., Lomonte, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076770/
https://www.ncbi.nlm.nih.gov/pubmed/32093386
http://dx.doi.org/10.3390/toxins12020131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076770/
https://www.ncbi.nlm.nih.gov/pubmed/32093386
http://dx.doi.org/10.3390/toxins12020131

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