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Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

The phospholipase A(2) (PLA(2)) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA(2) activity of a wide variety of snake venoms. In this study, the ability of these two forms of Varespladib to halt or delay lethality of potent neurotoxic...

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Detalles Bibliográficos
Autores principales:	Gutiérrez, José María, Lewin, Matthew R., Williams, David. J., Lomonte, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076770/ https://www.ncbi.nlm.nih.gov/pubmed/32093386 http://dx.doi.org/10.3390/toxins12020131

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