Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5

Although Rhesus macaques are an important animal model for HIV-1 vaccine development research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic determinant of this species-specific restriction is a non-synonymous mutation in macaque CD4 that results in reduced HIV-1...

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Detalles Bibliográficos
Autores principales: Roop, Jeremy I., Cassidy, Noah A., Dingens, Adam S., Bloom, Jesse D., Overbaugh, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077290/
https://www.ncbi.nlm.nih.gov/pubmed/32098152
http://dx.doi.org/10.3390/v12020241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077290/
https://www.ncbi.nlm.nih.gov/pubmed/32098152
http://dx.doi.org/10.3390/v12020241

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